Thanks so much in advance for any feedback. My RE didnt change a thing between round 1 and round 2, and I didnt do anything differently. I was exactly like you- I told myself and my RE that I refused to go through that devastation again so I wanted to do everything possible to make the outcome different. We have some sort of make factor at play but no other known fertility issues. Hello- The chances of having a positive outcome with PGS testing and IVF depend on the number of the produced embryos that have a positive result in the test. My husband and I started trying to get pregnant about a year ago (we're both 35). We got to see and hear the heartbeat yesterday. On September 20th, we did my first IVF cycle. It sucks cause I only have one shot left at this and Im already against odds cause its a day 7 embryo , So RE doesnt think i need ERA because I did get pregnant. It looks like at this time that it's implantation failure rather than abnormal embryos, since we got a good one from the ones we had tested. It's an autoimmune blood clotting disorder that can cause recurrent miscarriage. My RE also encouraged us to just try another transfer rather than an ERA after our first chemical but then was on board after the second chemical happened. PGS can increase the rate of clinical pregnancy. I am so frustrated, disappointed, hurt, sad and angry right now. Its not a ton of time to do and it might make the difference. Sounds like a beautiful a rainbow miracle! thats a great suggestion! Dr is responsible for allowing . We decided to see an RE given our age. Im willing to try anything :) thanks for sharing! Chemical pregnancy with PGS tested embryo. I an 33 and my husband is 37. 4 PGT-M and PGT-A vs. Prenatal Testing In large scale Double Blind Randomized Control Trials (the best method for medical protocol research) PGT did not increase your chances of pregnancy, except in some scenarios. I'm curious if this might have something to do with it. I know in our case our embryos had epigenetic issues which meant that our baby that we miscarried probably had structural issues. I am so so sorry. Weve spent almost 45K on this process and we are with a reputable clinic affiliated with CCRM so I am confident they know what they are doing but you cant also help but wonder is there more that can be done Im waiting to hear from the team to see if shes given some more thoughts. Have they tried changing your protocol (ie from natural to artificial cycle)? I'm sure that is REALLY frustrating to have a loss after spending all that money to get "good" embryos. I wanted to point out thestandard deviationof this data is large, roughly 30% for each group. No additional testing has been offered after 3 chemicals and one failed implantation on PGS normal embryos - he just tries to push me onto surrogacy each time saying sometimes thats the only option. Thanks for commenting! In contrast to mosaic embryos that are a mix of euploid and aneuploid cells, aneuploid embryos are completely aneuploid and all the cells are abnormal. Thanks for sharing! We started some workup with my OB (TSH, karyotyping and carrier testing). I actually didn't do acupuncture the second cycle, but I was in great shape. My lining a week before transfer was 6.8, but trilaminar lining was present. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). But if you dont like the extra meds you could talk with your current or new clinic about not doing it and get their thoughts on it. After a chemical with 2 PGS normals and two miscarriages around 8 weeks (spontaneous pregnancies) and another failed transfer, I found out I had an infection in my lining that can only be detected by a biopsy. I also stopped working night shifts (Im a nurse) to reduce my stress levels but that didnt help either. I encourage to keep pushing forward. Are you sure you want to block this member? It worked and now Im 24 weeks pregnant with twins! amazing, that gives me hope :) thanks so much! I am not naive I know bad things can happen. Why do we have to wait until we have a second devastating failure? I paid a fortune for those sessions (I dont have insurance). I would like to use the delestrogen shots next time instead of the patches and pills which seem to do nothing for me. In this post well learn more about IVF with PGS success rates for euploid embryos. Consult with your doctor before making any treatment changes. I expect a call from my RE tomorrow, will ask about both of your suggestions, the immune protocol and antihistamine and see what she thinks . For more up-to-date information on this topic check out my other posts that are tagged withPGS (PGT-A) success rates. Tiegs (2020) in their multicenter prospective study transferred 414 blastocysts that were only tested using PGT-A after the pregnancy outcome. Would love to hear if it was successful - fingers crossed . I honestly wish I had but thats all hindsight now knowing what I knew. My first FET was a day 6 5AA euploid embryo. (2019) STAR trial represents the best data that we have currently, and it shows no benefit with PGT-A reducing miscarriage in the general population. I am terrified he wont implant. Trying to be strong and not make the holidays about my loss for the sake of my family, not sharing the news either until after. I will ask my dr about this. For this group theyll have a better idea of what to expect. Im sorry for your loss My first was also a frozen transfer and I agree, there is more prep involved. Low mosaics had a miscarriage rate of 11.0%, None of these were statistically significant from the other (, Euploid embryos had an 8.6% miscarriage rate, All of the mosaics had a 20.4% miscarriage rate, <50% mosaic segmental embryos had a 13.6% chance of miscarriage, >50% mosaic segmental embryos had a 20.3% chance of miscarriage, <50% two whole chromosome mosaics had a 11.9% chance of miscarriage, <50% complex (>2 whole chromosomes) mosaics had a 26.7% chance of miscarriage, >50% two whole chromosome mosaics had a 39.9% chance of miscarriage, >50% complex (>2 whole chromosomes) mosaics had a 44.3% chance of miscarriage. Women over 35 were not shown to have increased pregnancy rates from PGT unless they made many embryos that needed evaluation. Autoimmune Testing? I'm in a similar situation so will ask my RE about all of this! Besides that, there are no gaurantees of both sticking. But Im wondering how those numbers have changed with other advancements in infertility medicine. HCG was 24 Friday and yesterday went down to 16. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. I'm 37 years old, and I just had a chemical pregnancy with a PGS-tested embryo. Capalbo et al. Ive seen conflicting studies with some (irani 2017) saying poor quality euploid has just 25% LBR but some more recent studies (2021) that suggest that morphology matters more under 30 (which Im not Im 42 but was 37/8 at retrieval). Im going to try and run it by her again to see what she thinks. Its good you will request the endomitritis biopsy. It provides a greater scope of information to geneticists, it reveals mosaicism within the embryos, as well as minimising the risk of receiving false positive or negative results. He earned his MSc in 2012 for his research on inflammation and lung cancerand started Remembryo in 2018 to help people understand the evidence behind common IVF topics. Ive had two chemicals and my RE suggested doing an endometrial receptivity assay (ERA). Was just curious if the percentages of a live birth increase after a positive pregnancy test. For women 35-40 years old, there was no statistical difference (8.2% for PGT-A vs 11.0% for untested). I have had my heart broken multiple times. I pay completely out of pocket for everything so the added expense was not something I wasnt looking forward to, but Im happy I went through with it. Hi.all0130could you tell me what kind of endometrial scratch biospy you did?hi.T3bk.you did endometrial scratch biospy too?which one you did?era.yale eft.or something else? Ive done 4 transfers now with PGS tested embryos - the first failed and the last 3 resulted in chemical pregnancies. Chemical pregnancy is an early miscarriage. Mosaic embryos can be either low- or high . My doctor thought it was possibly due to retained products of conception. Im currently 17 weeks from another FET. If your protocol did not have one or the other perhaps you can ask your RE about it. As mentioned in the study, about 72% of mosaic miscarriages occurred between observation of the gestational sac (3-5 weeks after transfer) and fetal heart beat (6-8 weeks after transfer). It wouldnt be going far at least. She said that this is something that is prevalent in recurrent pregnancy loss and failed implantations. By 40 theres about a 1 in 4 chance of not getting a euploid and by 43 this doubles to half. Best of luck! Congratulations on your success , I have a similar story. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). Did your doctor have your SO go through the rounds of antibiotics as well? Have you ever had an endometrial biopsy to look for infection? I also want to add low dose prednisone and lovenox - I have heard from so many of you that even IF no autoimmune issues are found that this combo helps. Wishing you lots of luck. (2018)looked ateuploidembryos (aCGH/SNP) in women <35: Irani et al. I'm glad we did - because my ERA results were abnormal and I needed 12 more hours of PIO. We have our lining check on Friday. As someone else mentioned adding prednisone, I also had a steroid but mine was the Medrol Dose pack which is basically the same idea. Im so confused as my RE says that morphology doesnt matter if theyre euploid. Hi, i didnt have chemicals, I had bfn for my first two transfers. The psychologist who ran the group, who also happened to be an RE at my fertility clinic, explained that sometimes you have a seemingly perfect embryo, perfect uterine lining, and the FET just fails. Good luck and dont give up on hope yet! You have to do whatever you feel comfortable with and its so unfortunate that money plays a huge role in these decisions. And my RE is kind of resistant to doing extra tests before I have a second failure, which I find a little crazy. Your clinic may have a better idea of how things work in their hands. When questioned as to why nothing was working, his response was sometimes it just doesnt happen and we dont know why. END MENTS. Starting in the late 1990s, doctors testing fertilized eggs classified them as normal or abnormal, then added the classification "mosaic" in 2015. It is seriously invaluable to me. They also provided information for the chance of getting no euploids per cycle: So as age increases, the chances of getting a euploid embryo drop. We timed everything to my cycle. In my case, my miscarriage was potentially caused by a partial uterine septate that my doctor identified via sonohystergram and removed via hysteroscopy. My first FET was a day 6 5AA euploid embryo. Does PGT-A reduce the chances of miscarriage? may be contradicted by other studies. So no one knew what was being transferred. Group Black's collective includes Essence, The Shade Room and Naturally Curly. At the time, I was at rock bottom and going to an online support group. There was also no difference with Day 7, although the sample size was very small. I go for my next Beta tomorrow. Pre-implantation Genetic Testing for Aneuploidies (also known as PGT-A, or historically known as PGS or CCS) is a diagnostic tool to tell your fertility doctor which embryos are likely to be chromosomally-normal and thus which to transfer. Bradley et al. ERA testing. I also am interested in doing an endo scratch beforehand and adding Viagra if the shots and scratch aren't doing the job. Try to take extra good care of yourself while you regroup from this cycle, and then go with your instincts for your next cycle. My questions is only 28% of our blastocysts passed pgs testing which is quite low from what is predicted for those under 35. We decided to start with IUI with clomid which resulted in another chemical pregnancy. (I was taking baby aspirin and Lovenox 2x/day for blood clotting disorders as well as Prednisone 30 mg /day and Intralipid transfusions weekly for elevated NK cells). Unfortunately this isnt very clear at this point. The only thing different medication wise was that I took a baby aspirin once daily starting the day of transfer the second time. We found out yesterday we were having a chemical pregnancy, my second beta didnt double. Like embryo grades in the previous section, it looks like IVF with PGS success rates may vary based on how fast the embryo develops, particularly for Day 7. I had a chemical with a PGS embryo in October. Reply Share React AMB425 Sep 2, 2016 11:01 AM There is much better chance of IVF success with PGS testing in women who were over the age of 35. My TSH was marginally high and I started synthroid. So in your case it might be different since yours are chemical pregnancies but still worth asking I think :) Also someone above mentioned the endometrial biopsy which would also probably be a good idea. Just thought Id throw this test out there though! LBR was associated with morphologic parameters of euploid blastocysts, especially in women <30 years old. Be sure to read the next two sections to get an idea of how grades and growth rates (Day 5, 6, 7) affect IVF with PGS success rates, as well as this section further down. This educational content is not medical or diagnostic advice. We had two from #4 cycle- one normal boy embryo and another that they said they didn't have enough material to test. By screening out abnormal embryos with PGS, physicians can transfer just one chromosomally normal embryo, increasing the chances for having a successful singleton pregnancy and healthy child. Hi Mogwai_2 Theses are rates for PGS normal embryos. 2 came back normal. Check here for the full. Our RE recommends trying again, but it feels like insanity to try the same thing without changing/adding anything or doing some tests. Thats a great suggestion, I will definitely ask my dr about doing an ERA. I feel like most times the protocol for autoimmune issues is the same. This was our first trial. My AMH was low, around 1.5, FSH was slightly high, and follicle count was low normal. Saw a heartbeat at 6 and 8 weeks then nothing at week 10. Are there recent numbers for this comparison? You guys have given me so much support and reassurance that I'm not alone in this ordeal. We PGS tested the whole batch of embryos at once at the end of all the retrievals. Yes, and I believe it was due to doctor negligence. I cried the whole way home. He earned his MSc in 2012 for his research on inflammation and lung cancerand started Remembryo in 2018 to help people understand the evidence behind common IVF topics. Aneuploids on the other hand, at least based on 1 study, seem to have a 100% miscarriage rate. Im glad you took time for your mental health. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Setting: University-based fertility center. Patients often hear "PGS-normal embryos have a 60 - 70% success rate." But that is on a per-transfer basis. Hello, This is all so hard and stressful. A doctor can confirm it by testing blood for human chorionic gonadotropin (hCG . Check here for the full. I"ve not had a chance to actually talk with my RE yet, hopefully I will tomorrow after I go back for monitoring. Im very sorry and hope you can find the strength to continue. Or is it worth having the actual tests done? Your post will be hidden and deleted by moderators. Thanks in advance! We Tested the tissue and it was normal (??). Genetic testing was normal. (2018)looked at about 650 transfers ofPGS tested euploidembryos (based onSNPtechnology) across various ages: So it looks like the success rates hover around 60-70% in most cases, with women >42 having about a 50% live birth rate per transfer. Im trying not to fixate on my last embryo being a day 7. Im still u sure if this will go to term, but getting a 2nd opinion from a specialist in RPL sure has made a difference. Some are faster, and some are slower. Some of the reasons quoted werent even about the patient: it could have been damaged during the biopsy or thaw process in the lab, the transfer process could have been off, theres a margin of error with the testing itself, pgs doesnt tell us everything about an embryo, etc. My second was ectopic, my third was a failure and Im about 7.5 weeks pregnant from my 4th (). We were told not to worry and try again after a month, and in March I found I was pregnant again but this turned out to be a chemical pregnancy. This test can identify chromosomally normal embryos, which increase the chances of a healthy pregnancy. Because of my age and being diagnosed with diminished egg reserve we did "embryo batching" and I had 4 rounds of egg retrievals before moving onto any transfers. So the advantage with PGT-A may be in determining which embryos are completely unfit for transfer, at least based on this study. 1) Has anyone else had the immune suppressing protocol NOT work, and then gone on to have it work? About 7 months later I transferred a day 7. Thank you TXtoCA, Im definitely planning to make changes. Trying naturally, assisted, etc. Please don't give up! I feel so lucky that I found this community. I also had a chemical with a PGS tested embryo. Did anyone else have success after failure with PGS? After my negative, we did ERA and had a hysteroscopy to correct a small septum. Success rates for graded euploids are given here https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates. See the chart below from the CDC (2016 data): In this post well look at the different miscarriage rates that all these types of PGT-A tested embryos have.
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