MORE, Evonik has developed a unique process for the structure treatment of its ultra-high purity IDISIL Colloidal Silica particles. J Colloid Interface Sci 353:115. The silica, together with other excipients, helps absorb and distribute the moisture, which yields uniform, free-flowing, and compactible granules. The table below provides a synopsis of the main physicochemical properties of importance. After opening, it should be stored in the refrigerator at 2-8C with the cap tightly closed during storage. Silica colloidalis anhydrica. Klaassen, D. Liebler, J.G. J Nanosci Nanotechnol 12:63466354. Langmuir 28:7598613. Particle sizes range from about 1 to 100 nm. Qsilica products do not contain any added gluten. https://doi.org/10.1039/b921735e, Daz B, Snchez-Espinel C, Arruebo M et al. Its usefulness stems from three key attributes: Colloidal silicon dioxide is used as a carrier for liquids and semi-liquids or as free-flow agent in powdered products (pharmaceuticals, cosmetics, salts, and foods), particularly for substances that attract water molecules (hygroscopic) or cake, so that they flow better. (2016) A comparison of techniques for size measurement of nanoparticles in cell culture medium. https://doi.org/10.2217/nnm.11.19, Xu H, Yan F, Monson EE, Kopelman R (2003) Room-temperature preparation and characterization of poly (ethylene glycol)-coated silica nanoparticles for biomedical applications. This versatility stems from its high absorptive capacity, ability to improve flow, and low dust content, as outlined in the table below: When applied to pharmaceutical products, the above-listed Silica attributes provide the following functionalities: Thus, Colloidal silicon dioxide functions, in both solid and liquid dosage forms, as a: In tablets, capsules, and granules, Colloidal silicon dioxide is popularly used as a glidant and anti-adherent, where it allows powder formulations to efficiently flow on high-speed tablet presses. https://doi.org/10.1021/cr60234a002, Kosmulski M (2016) Isoelectric points and points of zero charge of metal (hydr) oxides: 50 years after Parks review. Chem Mater 24:43264336. The colloidal suspension is stabilized by pH adjustment and then concentrated, usually by evaporation. We present the impact of media and particle characteristics on silica nanoparticles degradation. https://doi.org/10.1021/j100812a002. Qsilica offers a convenient form of colloidal silica, a dietary mineral that supports skin, hair and nail health. https://doi.org/10.1021/nl404316v, Yamada H, Urata C, Aoyama Y et al. Thus, the understanding of the silica NPs behavior in body fluids is essential for the approval of nanomedicines and, therefore, more investigations concerning the dynamics, thermodynamics, biological response, and structural parameters of silica-based NPs are of utmost importance. What kind of suspension is a colloidal silica? Int J Pharm 572:118782. https://doi.org/10.1016/j.ijpharm.2019.118782, Li XW, Zhao WR, Liu YJ et al. https://doi.org/10.1021/ja01465a001, Depasse J, Watillon A (1970) The stability of amorphous colloidal silica. https://doi.org/10.1021/acsami.6b05099, Plmai M, Nagy LN, Mihly J et al. https://doi.org/10.1002/smll.202101519, Bhavsar D, Patel V, Sawant K (2019) Systemic investigation of in vitro and in vivo safety, toxicity and degradation of mesoporous silica nanoparticles synthesized using commercial sodium silicate. https://doi.org/10.1021/la500057j, Knop K, Hoogenboom R, Fischer D, Schubert US (2010) Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Generally, the viscosity of obtained gels depends on the amount of silica added; that is, the more is added, the thicker the gel will be. In addition, the Qsilica ONE-A-DAY range also contains biotin, zinc and selenium for added skin, hair and nail health and protection against free radical damage. Acta Biomater 84:317327. The liquid can be added to smoothies or a water bottle for consumption throughout the day. (2013) Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility. https://doi.org/10.1016/S0001-8686(02)00061-1, Bharti B, Meissner J, Klapp SHL, Findenegg GH (2014) Bridging interactions of proteins with silica nanoparticles: the influence of pH, ionic strength and protein concentration. However, it should not be administered parenterally, because untoward tissue reactions or the formation of granulomas could occur. J Mater Chem B 5:435443. https://doi.org/10.1021/cm0112441, Chen JF, Ding HM, Wang JX, Shao L (2004) Preparation and characterization of porous hollow silica nanoparticles for drug delivery application. The products are not to be mistaken as "colloidal silica" or "silica sol" which stands for dispersions of Adv Ther 3:1900110. https://doi.org/10.1002/adtp.201900110, Moore TL, Rodriguez-Lorenzo L, Hirsch V et al. Suitable for formulating soft powder formulations. (2020) Targeted GSH-exhausting and hydroxyl radical self-producing manganesesilica nanomissiles for MRI guided ferroptotic cancer therapy. (2019) Reducing protein corona formation and enhancing colloidal stability of gold nanoparticles by capping with silica monolayers. J Mater Chem 20:86938699. (2007) Kinetic and thermodynamic studies of silica nanoparticle dissolution. https://doi.org/10.1038/359710a0, Tarn D, Ashley CE, Xue M et al. Many people like the ease and convenience of taking a tablet or capsule these are also ideal for travelling. It is advised to only take Qsilica products when they are in-date. Spilled material should be collected without any dust being formed and placed in a suitable container. AEROPERL 300 Pharma, which like standard Colloidal silicon dioxide, is tested against the high-quality requirements of the Silica Colloidal Anhydrous (Ph. The term nano silica can also have a wider definition and include other types of silica in powder form. The production process does not involve plant or animal based raw materials, nor does it involve organic solvents. Int J Pharm 361:177188. https://doi.org/10.1039/c3sm52401a, Grasso D, Subramaniam K, Butkus M et al. Qsilica PRO COLLAGEN also contains a combination of wheat ceramides (Ceramosides) and vitamin C in addition to mineral silica, to promote collagen production. All respective intellectual property, such as trademarks and logos, are properties of their owners. (2009) Novel zwitterionic-polymer-coated silica nanoparticles. https://doi.org/10.1039/c1cs15233e, Vroman L, Adams A, Fischer G, Munoz P (1980) Interaction of high molecular weight kininogen, factor XII, and fibrinogen in plasma at interfaces. Speciality granulated silica grades consisting of spherical particles in the range of 10100 m that feature a high internal surface (mesoporous) and high density can be used in the above-mentioned formulation strategies aimed at enhancing solubility and dissolution. https://doi.org/10.1021/la201940r, Croissant JG, Fatieiev Y, Khashab NM (2017) Degradability and clearance of silicon, organosilica, silsesquioxane, silica mixed oxide, and mesoporous silica nanoparticles. If you are pregnant, considering becoming pregnant or breastfeeding, we recommend seeking professional health care advice from your practitioner prior to making any dietary changes such as incorporating a supplement into your routine. Chemical names Silicon dioxide, chemically prepared C.A.S. It can, consequently, lead to the NPs aggregation and affect their degradation profile. Because of the very small size, the surface area of colloidal silica is very high. We recommend selecting the Qsilica product that most closely suits your needs and therefore combining Qsilica products together should not be necessary. It can be found in nature in crystalline form (as quartz sand), and it is the most abundant component of the earth's crust. da Cruz Schneid, A., Albuquerque, L.J.C., Mondo, G.B. https://doi.org/10.1039/C8MH01527A, Picco AS, Mondo GB, Ferreira LF et al. Colloidal silicon dioxide is an effective excipient for stabilizing dispersions of solids in liquids and preventing the formation of hard sediments in liquid suspensions and aerosol formulations intended for topical (rather than inhalation) use. Nat Mater 8:543557. This is especially relevant for poor glass forming APIs, which can be difficult to stabilize with other formulation technologies. et al. Finally, the viscosity of sodium silicates is much higher - closer to that of a syrup, while colloidal silicas have viscosities close to that of water. (information required on hydrated silica, silica aerogel and colloidal silica) Chemical names Silicon dioxide C.A.S. https://doi.org/10.1002/anie.201508288, Lu J, Liong M, Li Z et al. These hard capsules are suitable for vegans and vegetarians. Several forces are at play when it comes to particle-particle interactions, and, thus, powder cohesiveness and flow. It's found in plants, animals and most living things. Working Hours (Mon to Friday): 08:30 - 17:30. The following regulatory schedules apply to colloidal silicon dioxide: Several grades of colloidal silicon dioxide are widely available, depending mainly on the method of production, and any subsequent processing changes that the material is subjected to. Standard colloidal silica dispersions are stable against gelling and settling in pH range of 8 - 10.5. If magnesium stearate is used, colloidal silica should be mixed with the other ingredients first before adding in the lubricant. https://doi.org/10.1039/C6TB00718J, Fontecave T, Sanchez C, Azas T, Boissire C (2012) Chemical modification as a versatile tool for tuning stability of silica based mesoporous carriers in biologically relevant conditions. When silica is being handled, electrostatic charging can occasionally occur, for example when the silica sack is being emptied. The subunits of colloidal silica particles are typically in the range of 1 to 5nm. https://doi.org/10.1039/C3MH00106G, Nel AE, Mdler L, Velegol D et al. Silica is an ultra-trace element (required in small amounts) involved in the formation of bone, teeth and cartilage. Low pH grades can also be obtained by completely deionizing the dispersion.These grades do not require the presence of stabilizing ions and are also stable below a pH of 3. (2020) Degradation of silica particles functionalised with essential oil components under simulated physiological conditions. (2013) Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology. Marks, R.C. Qsilica ONE-A-DAY tablets are oval shaped and approximately 22mm long by 10mm wide. SiO2 Mr 60.1 [7631-86-9] DEFINITION Colloidal anhydrous silica contains not less than 99.0 per cent and not more than the equivalent of 100.5 per cent of SiO2, determined on the ignited substance. Within the construction industry aqueous dispersions of colloidal silica are also referred to as nano silica and used for example in geotechnical, shotcrete and other concrete applications. Precipitated silica, on the other hand, is mesoporous and exhibits an internal surface. The silica should be dispersed in the medium that contains the active ingredient, polymer (adhesive) and/or other excipients. Colloidal (sol-gel) silica particles typically have a spherical or oblong shape with a . While the primary structure is the tetrahedron, consisting of one silicon atom bonded to four oxygen atoms, tetrahedrons arrange into networks. Adv Funct Mater 28:1707325. https://doi.org/10.1002/adfm.201707325, Fuentes C, Ruiz-Rico M, Fuentes A et al. In numerous studies, it has been shown that in the bulk phase (normal existence), the primary particles in Colloidal silica do not exist as individual/discrete nanoparticles but are fused together to form aggregates, which subsequently form agglomerates. Chem Mater 19:41894197. It is these aggregates that partly contribute to the unique functionalities of amorphous silicon dioxide. Flint is a form of silica that was used in ancient tools.The sand used in pottery is also a form of silica. Google Scholar, Bogush GH, Tracy MA, Zukoski CF (1988) Preparation of monodisperse silica particles: control of size and mass fraction. Mater Horiz 1:301313. At rest, however, the lattice rebuilds, and the viscosity returns to what it was before, a phenomenon known as thixotropy. (2021) Manganese-doped gold core mesoporous silica particles as a nanoplatform for dual-modality imaging and chemo-chemodynamic combination osteosarcoma therapy. (2009) Intracellular localization and cytotoxicity of spherical mesoporous silica nano- and microparticles. https://doi.org/10.1021/ja951550d, West R, Whatley LS, Lake KJ (1961) Hydrogen bonding studies. Many plants use silica to stiffen stems for holding fruit and to form external needles for protection. Evonik complements product portfolio with Colloidal Silica - as a specialty chemicals company, Evonik is specialized on particle modification and functionalization for ultra-high purity Colloidal Silica. https://doi.org/10.1006/jcis.1994.1242, Adler JJ, Rabinovich YI, Moudgil BM (2001) Origins of the Non-DLVO force between glass surfaces in aqueous solution. Be the first to know about exclusive offers, new products, expert tips and delicious recipes. Benefits of silica from Evonik for the pharmaceutical industry. Colloids Surf B Biointerfaces 186:110677. https://doi.org/10.1016/j.colsurfb.2019.110677, Monopoli MP, Walczyk D, Campbell A et al. In Europe, Colloidal silica is designated E551. (2020) Zwitterionic stealth dye-loaded polymer nanoparticles for intracellular imaging. Microporous Mesoporous Mater 248:4653. Langmuir 27:1016710173. (2012) Effects of the presence or absence of a protein corona on silica nanoparticle uptake and impact on cells. Dispersions with a smaller average diameters have larger overall specific surface areas and are limited to low concentration dispersions. https://doi.org/10.1021/cm070708d, Etienne M, Walcarius A (2003) Analytical investigation of the chemical reactivity and stability of aminopropyl-grafted silica in aqueous medium. Langmuir 27:98239833. [8] Sccs, P.H.M. Finally, fumed silica is commonly referred to as colloidal because the silica powders are made by condensing a silica precursor from a vapour phase. 1 This brochure uses the term "colloidal silicon dioxide" in the sense of the USP/NF monograph for silica products produced by flame hydrolysis. J Colloid Interface Sci 133:105117. Langmuir 27:67946800. Colloidal silicon dioxide has the chemical formula SiO2 but is distinct from other types of silica, such as amorphous or crystalline silica, that exist naturally or otherwise such as silica gel or precipitated silica. 7631-86-9. https://doi.org/10.1016/0009-2614(92)85309-X, Pfeiffer-Laplaud M, Costa D, Tielens F et al. https://doi.org/10.1039/c3cc41062e, Yu L, Chen Y, Wu M et al. (2017) Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality. https://doi.org/10.1016/j.actbio.2018.12.012, Scheffer FR, Silveira CP, Morais J et al. John Wiley & Sons, Inc. Kosmulski M (2009) Compilation of PZC and IEP of sparingly soluble metal oxides and hydroxides from literature. ACS Appl Mater Interfaces 7:1382113833. (2001) Alkali-treatment techniquenew method for modification of structural and acid-catalytic properties of ZSM-5 zeolites. (2011) Phase behavior of poly(sulfobetaine methacrylate)-grafted silica nanoparticles and their stability in protein solutions. Small 5:27222729. Colloids Surf B Biointerfaces 126:251256. J Colloid Interface Sci 553:540548. J Biomed Mater Res A 66:870879. No express or implied warranty is made for specific properties or fitness for any particular application or purpose. J Biomed Mater Res 25:13971407. Our portfolio includes colloidal and composite materials with a range of particle sizes and treatments, allowing for the controlled tuning of performance characteristics such as tribocharge, free-flow and spacing. Vegetable Oil Hydrogenated Excipient | Uses, Suppliers, and Specifications, Magnesium Trisilicate Excipient | Uses, Suppliers, and Specifications, Hydrated Colloidal Silica Excipient | Uses, Suppliers, and Specifications, Kaolin Excipient | Uses, Suppliers, and Specifications, Magnesium Silicate Excipient | Uses, Suppliers, and Specifications, Under Section 107 of the Copyright Act 1976, Hydrophobic Colloidal Silica Excipient | Uses, Suppliers, and Specifications, Sodium Stearyl Fumarate Excipient | Uses, Suppliers, and Specifications, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, Monograph Silica, Colloidal Anhydrous, Fluffy, poorly flowing or free-flowing powder, Colloidal silica is hygroscopic. In general, these forces include but are not limited to van der Waals forces, electrostatic forces, liquid bridges, and physical entanglements. Langmuir 36:1075610763. Present technology would be very different without the silica used to create the catalysts of our oil refineries, bind the molds for casting super-alloys, form modern glass and ceramics, and polish electronic materials. https://doi.org/10.1039/d0nr09220g, Marques MRC, Loebenberg R, Almukainzi M (2011) Simulated biological fluids with possible application in dissolution testing. No, all of our Qsilica products are 100% vegan and cruelty-free and therefore contain no animal ingredients. Thus, it obviously alters the interactions of the particles with cellular and tissue components, ultimately modifying biological outcomes such as cellular uptake, immune-biocompatibility, and toxicity of NPs [39, 52,53,54]. https://doi.org/10.1016/j.cej.2017.12.116, Safavi-Sohi R, Maghari S, Raoufi M et al. Lipid formulations: Solutions of API in suitable oil carriers can be absorbed by the mesoporous silica, which can then be converted into free-flowing powders. Angew Chem Int Ed 49:62886308. J Mater Chem B 4:43134321. J Mater Chem 20:27802787. Surf Sci Rep 69:132158. A dust mask with particle filtering capability should be worn if high concentrations of dust are generated in the work environment. Hi I'm a vegan. https://doi.org/10.1039/c4cs00487f, Tenzer S, Docter D, Kuharev J et al. https://doi.org/10.1002/adma.200901263, Rosen JE, Gu FX (2011) Surface functionalization of silica nanoparticles with cysteine: a low-fouling zwitterionic surface. There are no contraindications for silica during pregnancy or breastfeeding and therefore, with advice from your medical professional Qsilica ORIGINAL Skin, Hair, & Nails Capsules can be considered for use during pregnancy. An example of such mesoporous Colloidal silicon dioxide is AEROPERL 300 Pharma (Evonik AG). https://doi.org/10.1016/0021-9797(89)90285-3, Sverjensky DA (2005) Prediction of surface charge on oxides in salt solutions: revisions for 1:1 (M+L-) electrolytes. Thirdly, protection from heat and frost is recommended, and temperature excursions above 35 C can alter the materials physicochemical properties. https://doi.org/10.1016/S0927-7757(01)00845-7, Hiemstra T, De Wit JC, Van Riemsdijk W (1989) Multisite proton adsorption modeling at the solid/solution interface of (hydr)oxides: a new approach. Nanoscale 12:26262637. The importance of drug dissolution and permeability has been previously described by the Biopharmaceutics Classification System (BCS), originally proposed by Amidon, which groups APIs into four different classes according to their permeability and solubility in aqueous media, namely, BCS I, II, III and IV. It is obtained through chemical synthesis using a suitable silicon compound precursor, such as silicon tetrachloride, typically at temperatures >2000 o C. Chemistry 22:1480614811. Another important property of synthetic silica is its specific surface area. . https://doi.org/10.1016/j.colsurfa.2019.04.055, Lei Q, Guo J, Noureddine A et al. Many challenges one solution: Fumed and precipitated silica from Evonik are some of the most important and highly used pharmaceutical excipients. Colloidal silicon dioxide can be used in membrane-controlled and matrix-controlled transdermal drug delivery systems as a gel former or to increase storage and thermal stability. This should be done with the most cohesive ingredient, if present. Pyrogenic silica is produced in an anhydrous state, whereas the wet process products are obtained as hydrates or contain surface absorbed water. J Colloid Interface Sci 533:463470. All forms of Silica, whether natural, synthetic, crystalline, cryptocrystalline or amorphous, are assigned a single CAS Registry number [7631-86-9]. Belsito, R.A. Hill, C.D. According to the definition of ISO TS 80004-1, Colloidal silicon dioxide (and other synthetic amorphous silicas) are nanostructured. The highest amount of colloidal silicon dioxide (hydrophilic) approved so far per dosage form can be found in the FDAs Inactive Ingredients Guide Database: http://www.accessdata.fda.gov/scripts/cder/iig/index.cfm. [7] D. Majerov, L. Kulaviak, M. Rika, F. tpnek, P. Zmostn, Effect of colloidal silica on rheological properties of common pharmaceutical excipients, European Journal of Pharmaceutics and Biopharmaceutics, 106 (2016) 2-8. Colloidal is used in reference to both pyrogenic and precipitated silica. https://doi.org/10.1016/0021-9797(70)90235-3, Allen LH, Matijevi E (1969) Stability of colloidal silica. https://doi.org/10.1016/j.biomaterials.2017.02.018, Article https://doi.org/10.1021/acs.langmuir.8b01550, Loiola LMD, Batista M, Capeletti LB et al. Nanoscale 13:753762. Note that the International Union of Pure and Applied Chemistry (IUPAC) defines colloids as systems (dispersions) in which particles of colloidal size (1 nm1000 nm) of any nature (solid, liquid, or gas) are dispersed in a continuous phase of different composition or state. Nanomaterials 7:162. https://doi.org/10.3390/nano7070162, Lin Y, Abadeer N, Hurley KR, Haynes CL (2011) Ultrastable, redispersible, small, and highly organomodified mesoporous silica nanotherapeutics. Microporous Mesoporous Mater 314:110886. https://doi.org/10.1016/j.micromeso.2021.110886, Carvalho GC, Sbio RM, de Cssia Ribeiro T, et al. Silica NPs can be synthesized in a wide variety of morphologies, porosity levels, and sizes. Microporous Mesoporous Mater 141:199206. Biomacromolecules 15:18451851. Qsilica products are made by the beauty of nature and innovated by the beauty of science. Both effects are based on the ability of dispersed Colloidal silica particles to form a network of aggregates via hydrogen bridge linkage and/or van der Waals attractive forces in liquid media. (2002) A review of non-DLVO interactions in environmental colloidal systems. It is recommended to use rotor-stator or dissolver homogenisers having a tip speed of 15 m/sec or more. https://doi.org/10.1016/j.cis.2015.10.009, Tiemblo P, Garca N, Hoyos M et al. (2018) Mesoporous core-shell silica nanoparticles with anti-fouling properties for ovarian cancer therapy. https://doi.org/10.1002/smll.200800199, Zhu Y, Fang Y, Borchardt L, Kaskel S (2011) PEGylated hollow mesoporous silica nanoparticles as potential drug delivery vehicles. To avert any risk during handling, measures should therefore be taken to prevent electrostatic charging. Owned & exclusively distributed in Australia by Planet Health.Exclusively distributed in New Zealand bySynergy NZ.Exclusively distributed in the UK byLime Health. (2014) Biodegradable ethylene-bis(propyl)disulfide-based periodic mesoporous organosilica nanorods and nanospheres for efficient in-vitro drug delivery. It allows formulation ingredients to be uniformly distributed throughout the suppository base. Any information provided on our platform is for general informational and educational purposes only. period: 24 CAB-O-SIL TG-C series of colloidal silica. Nonetheless, biological barriers can decrease the success of translating them for therapeutic applications since the media composition can induce their colloidal stability loss.
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