2007 Nov 14;55(23):9465-9. doi: 10.1021/jf072122h. Repeat the spraying in 7 to 10 days. Read more: How do you keep magnolias healthy? The disease results in large growths on the tree that are much larger than the branch or trunk on which they are growing. Users of this Web site should not rely on information provided on this Web site for their own health problems. 2014 May;12(2):96-102. doi: 10.1111/idh.12047. PMID: 27669240; PMCID: PMC5085662. One of the important jobs of the kidneys is to clean the blood. As a well-known insulin resistance regulator, PGC-1 also has been reported to exert anti-inflammation effects by multiple mechanisms [2729]. This is why its best to speak with your healthcare provider before taking magnolia bark alone or in combination with other supplements and medications. However, no effective therapeutic method for obesity-associated kidney disease is available. The bark of Magnolia oficinalis has been used in traditional Chinese medicine for centuries to address anxiety and nervous tension and to promote sleep. We hope that further research will confirm our hypothesis. 19 Magnolia Bark Medicinal Uses (Kidney Failure Side Effects? A voucher specimen was deposited at the Herbarium of Chungbuk National University, Chungbuk, Korea. Anti-inflammatory: helps reduce redness, irritation, and soothes the skin. Diabetes mellitus is a chronic metabolic disease characterized by disturbances in carbohydrate, protein, and lipid metabolism, often accompanied by oxidative stress. 1999 Jun;33(6):1364-8. doi: 10.1161/01.hyp.33.6.1364. A chemical in magnolia reduced damage in the. PMID: 7310672. Additionally, the magnolol appeared to increase the number of times the mice woke up during sleep but decrease the length of time they were awake. It is generally considered safe if taken orally and for the short term. Evidence in studies with menopausal women suggests that Magnolia Bark extract may decrease the frequency and severity of menopause symptoms including: Menopausal women taking Magnolia Supplements may experience some side effects including: One study treated menopause patients with a dosage of one 60mg tablet of Magnolia Bark extract daily for 24 weeks. Antitumor and antiangiogenic properties of honokiol are attributed to NF-kB inhibition and the consequent scavenging of reactive oxygen species(24). If you use magnolia bark extract directly on the skin, the best way is with a solubilizer such as Pentylene Glycol Natural. Luo J, Xu Y, Zhang M, Gao L, Fang C, Zhou C. Magnolol inhibits Lps-induced inflammatory response in uterine epithelial cells: magnolol inhibits Lps-induced inflammatory response. Drug users may misuse magnolia bark for its feel-good effect. Excess stress is a common problem. Try to keep your magnolia tree undamaged. Such leaves usually die after a while. MG132 is a peptide aldehyde proteasome inhibitor and exerts its therapeutic effects by reducing the degradation of ubiquitin-conjugated proteins such as nuclear-factor-E2-related-factor-2 (Nrf2), an important transcription factor regulating cellular defenses against reactive oxygen species, through inhibiting activity of the subunits of the core particle of 26S proteasome [38]. The women experienced significant improvements in insomnia, anxiety, mood, and irritability (31). Wood decay is a rather serious disease that affects the trunk of the tree. 5) and concentrated under reduced pressure to obtain viscous dark-brown residue (360g, BL153). PMID: 31240205; PMCID: PMC6556366. My HWP has magnolia bark combined with PEA for pain in a . Therefore, magnolia bark could be used as a remedy for insomnia or simply to promote better sleep overall. Although remarkably elevated in HFD-fed mice at the end of experiment, ACR was significantly reduced after administration with BL153 at the dose of 5mg/kg or 10mg/kg for six months (Figure 1). Regulation of Mucin 1 and multidrug resistance protein 1 by honokiol enhances the efficacy of doxorubicin-mediated growth suppression in mammary carcinoma cells. One study found that breath mints made with magnolia bark helped kill the oral bacteria that causes bad breath and tooth decay within 30 minutes, suggesting that magnolia bark in gum and mints may make visits to the dentist's office much more pleasant. Huang HC, Hsieh WY, Niu YL, Chang TM. Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo. In human endothelial cells, honokiol inhibited vascular endothelial growth factor receptor 2 phosphorylation(25). Symptoms are bark deformation in the place where the disease is developing. Also, supplementation with magnolia bark is not recommended in pregnant and breastfeeding women. The disease is most active during the warm summer months. Preclinical studies suggest these compounds have antimicrobial(1)(2), anti-inflammatory(3)(4) , antidiabetic(5)(6), antidepressant(7), anxiolytic(8), and neuroprotective(9) effects. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Mean glomerular area was also measured to evaluate the glomerular enlargement. Bethesda, MD 20894, Web Policies Insulin-induced hexokinase II expression is reduced in obesity and NIDDM. 2013 Sep 11;4:130. doi: 10.3389/fneur.2013.00130. Often it will dry out on the stem and have a whitish color. 2010 Sep 16;15(9):6452-65. doi: 10.3390/molecules15096452. After that, accumulating evidence supported that obesity is an independent risk factor for renal structural and functional changes, leading to end-stage renal disease which brings the society a heavy economic burden [2, 3]. Thirty mice were randomly divided into six groups (n = 5) and fed either an LFD (10% kcal as fat; D12450B, Research Diets Inc. NJ) or an HFD (60%kcal as fat; D12492B, Research Diets Inc. NJ) with or without BL153 for six months. A combination of honokiol and magnolol normalized biochemical abnormalities in brain 5-HT and 5-HIAA, serum corticosterone levels, and platelet adenylyl cyclase activity, a biomarker for depression in chronically stressed rodents(7). 2005 Apr;71(4):338-43. doi: 10.1055/s-2005-864100. These effects were enough for an introduction as a cosmetic material in moisturizers and face washes to alleviate irritated skin or manage skin diseases such as acne and atopic dermatitis. Teng CM, Chen CC, Ko FN, Lee LG, Huang TF, Chen YP, Hsu HY. Anxiolytic effects of honokiol are attributed to its selective stimulation of GABA-A receptors or its binding to anxiety-related sites(8). P < 0.05 versus HFD group. HK II expression was detected by western blot assay. When watering, be careful not to drip onto the leaves. The air-dried bark of M. officinalis (3kg) was cut into pieces and extracted twice with 95% (v/v) ethanol (4 times as much as the weight of the dried plants) for 3 days at room temperature. PGC-1 and NQO1 expression was detected by western blot assay. For example, because magnolia bark supplements may promote sleep in some individuals, its probably best not to take the supplements in combination with any other type of sedative or sleeping pill. Western blot assay were performed for measuring the expression of inflammatory cytokines and TNF- (a) and PAI-1 (b). Click the links below to access the individual topic pages: This article makes use of information from the U.S. National Library of Medicine under the terms of the Creative Commons Attribution 4.0 International License. I bought this item because I read a scientific study which said that magnolia bark extract has been able to stop kidney disease from progressing. Antimicrobial activity of phenolic constituents of Magnolia grandiflora L. J Pharm Sci. The leaf may darken or turn brownish green. Strain the liquid and remove any petals before drinking the petal tea. Moisturizer: prevents the loss of skin elasticity and reduces small wrinkles. 2017 Nov;43(6):760-769. doi: 10.1002/biof.1385. Accessibility Visit the Spanish-English Forum. This makes sense, as its known that GABA(A) receptor activity is closely associated with sleep (29). 2019 May 23;2019:1847130. doi: 10.1155/2019/1847130. Cavero RY, Akerreta S, Calvo MI. 2017 Mar.;18(3):194-214. We used Image Quant 5.2 to analyze western blotting. 2008 Apr 21;7:11. doi: 10.1186/1475-2891-7-11. This article reviews what it is, its best uses, potential benefits, and side, Suma root has many medicinal uses in folk medicine, but scientific evidence supporting its purported benefits is lacking. PMID: 22429472; PMCID: PMC3325890. Therefore, the gavage volume was 1%(mL/g) of mouse body weight (e.g., 25g mouse should be given 250L). It does help relax me and it does seem to relieve the kidney pain. J Int Soc Sports Nutr. People who are unaware of potential addiction-causing effects of magnolia. PMID: 20190404. The International Obesity Task Force has determined that the global numbers of adults and school-aged children considered obese in 2010 were 600 million and 50 million, respectively. Statistical significance was considered as P < 0.05. Chiang J, Shen Y-C, Wang Y-H, et al. As a library, NLM provides access to scientific literature. As the worldwide prevalence of obesity is increasing, more attention has been given to obesity-related complications, including kidney disease. sharing sensitive information, make sure youre on a federal Additionally, a test-tube study found that magnolol inhibited the growth of lung cancer cells (21, 22). Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. Neolignans are a type of polyphenol micronutrient in plants. Magnolia bark extract can be found at most supplement retailers. Urinary albumin and creatinine levels were examined to reflect renal function. In one study, a treatment containing magnolia extract was linked to less anxiety in menopausal women. Data in humans are limited. Here are 15 herbs with powerful antiviral properties. Taking magnolia bark along with drugs that promote sleep or treat anxiety, such as sedatives, sleep medications, and barbiturates, may cause drowsiness. In our present study, a novel finding was that PGC-1 was increased by more than 10-folds after BL153 treatment. As shown in Figure 5, kidney PGC-1 was slightly increased in HFD mice compared with LFD mice, and it was further increased after six-month BL153 treatment at indicated doses (Figure 5(a)). At the end of experiment, after urine samples were collected, all mice were sacrificed for further analysis. On the other hand, Magnolia bark offers short-term protection to kidneys against the toxicity induced by anticancer treatment. Several previous studies about magnolia extract obtained similar conclusions. Tear off leaves that have more than four or five spots on them. One way in which honokiol may combat cancer is by helping regulate cell signaling pathways. Biochem Pharmacol. Magnolia bark can also be toxic and has been linked to kidney disease and permanent kidney failure. Other anti-inflammatory markers reduced by magnolia bark extract include IL-6 as well as MMP2 and MMP9(4). Over time, this spot becomes increasingly pale until the tissue dies and a brown spot appears. Potential role for Nrf2 activation in the therapeutic effect of Mg132 on diabetic nephropathy in Ove26 diabetic mice. 2016 Sep 24;17(10):1629. doi: 10.3390/ijms17101629. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Suppression of, Semple RK, Crowley VC, Sewter CP, et al. It usually affects older trees. Try to keep the water droplets away from the leaves while watering. Western blot assay was performed as previously reported [37]. Weisinger RS, Stanley TK, Begg DP, Weisinger HS, Spark KJ, Jois M. Angiotensin converting enzyme inhibition lowers body weight and improves glucose tolerance in C57BL/6J mice maintained on a high fat diet. No adverse effects related to magnolia bark or the compounds it contains have been observed. Expression of the thermogenic nuclear hormone receptor coactivator PGC-1. In traditional Chinese medicine, magnolia bark is often harvested by being peeled or cut away from the tree. Its vasorelaxant action and antioxidant properties may contribute to reducing elevated blood pressure. BL153 ameliorated obesity-induced renal oxidative stress. In research, changes in levels of methane dicarboxylic aldehyde are often interpreted as a sign of antioxidant activity. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. Selection of 5mg/kg and 10mg/kg for the present study was based on a previous study [42], where treatment with BL153 at these two dose levels for a week showed a significantly protective effect. Zhang YK, Wu KC, Liu J, Klaassen CD. Magnolias have always been highly sought-after trees in the yard. PMID: 17949053. Magnolia bark is a popular herb in traditional Chinese and Japanese medicine. All information in this website is for informational and/or entertainment purposes only, and is not reviewed by any qualified medical professional, and it is not intended to be a substitute for professional medical advice. However, these studies used magnolia in combination with other compounds. A white substance that resembles powder appears on the leaves. The bark, leaves, and flower buds of the Magnolia tree have many medicinal uses that have been studied in medical literature, including the following: In the video below, Dr. Lindsey talks about the benefits of Magnolia Bark Extract: This is our recommended Magnolia supplement (Amazons Choice): The following are some side effects of magnolia bark: These side effects are rare and magnolia bark is safe for most adults for short-term use for up to 1 year. Last medically reviewed on April 7, 2020, Cissus quadrangularis is a plant that has long been used as a natural remedy to treat a wide variety of ailments. From diagnosis to treatment, our experts provide the care and support you need, when you need it. Comparisons between groups were performed by one-way ANOVA, followed by Tukey's post hoc test. Some studies have prescribed concentrated magnolia bark extracts for up to 1 year without any observations of adverse effects (1). 2016 Dec 4;193:657-662. doi: 10.1016/j.jep.2016.10.016. In murine models, honokiol enhanced low-dose docetaxel treatment against prostate cancer growth and bone metastasis(37), and reduced breast tumor growth biomarkers(48). Magnolia may protect. Controlled clinical study in menopause. National Library of Medicine In current study, we provide the first evidence that magnolia extract, BL153, attenuates obesity-associated renal structural and functional changes in an HFD-induced obesity mouse model. This article reviews galangal root's benefits and safety, as well as how it, Elecampane root is a folk medicine that may have several health benefits. Neuropharmacology. Small studies in humans suggest magnolia may help relieve menopausal symptoms, manage weight, and maintain oral health. One of the representative medicinal plants is the Magnolia genus, which is mainly distributed in East and Southeast Asia. n = 5; *P < 0.05 versus LFD group; # 2008 Apr 1;32(3):715-25. doi: 10.1016/j.pnpbp.2007.11.020. Here are common signs of too much stress. This suggests that it has potential as a therapeutic agent for neurodegenerative diseases like Alzheimers. 1981 Aug;70(8):951-2. doi: 10.1002/jps.2600700833. The bark of Magnolia officinalis were purchased from Kyungdong market, Seoul, Korea and was taxonomically identified by Dr. Ban Yeon Hwang at the Research Institute of Drug Resource, Chungbuk National University (Cheongju, Korea). 2005 - 2023 WebMD LLC, an Internet Brands company. To make sure the crucial role of PGC-1 and HK II in BL153-associated kidney prevention during obesity, PGC-1 and HK II knockout animals should be used. the contents by NLM or the National Institutes of Health. Here are 15 effective ways to relieve stress and anxiety. Rajgopal A, Missler SR, Scholten JD. The supplement can not only help improve sleep, stress, anxiety, and symptoms of menopause but also may have anticancer and antioxidant properties. n = 5; *P < 0.05 versus LFD group; # A similar study in more than 600 menopausal women found that consuming a magnolia bark supplement daily for 12 weeks relieved symptoms of insomnia, irritability, and anxiety (32). Effects of chronic treatment with honokiol in spontaneously hypertensive rats. Honokiol dimers and magnolol derivatives with new carbon skeletons from the roots of, Yu S-X, Yan R-Y, Liang R-X, Wang W, Yang B. Bioactive polar compounds from stem bark of. Lee Y-J, Lee YM, Lee C-K, Jung JK, Han SB, Hong JT. Thromb Res. Research on honokiol has found that it can reduce inflammation in the brain and spinal cord specifically, partly due to its ability to cross the blood-brain barrier (14). Afterward, feed the tree with a multi-purpose fertilizer. This research looked at both lab trails and human trails. Biol Pharm Bull. doi: 10.1631/jzus.B1600299. With cancer, where you get treated first matters. Also black necroses appear in the most severely affected places. Statistical analysis was performed with Origin 7.5 Laboratory data analysis and graphing software. However, Zhang et al. If the infestation is on the branch, cut it off below the affected area. Magnolol demonstrated activity against a variety of cancers, including bladder(10)(11)(12), prostate(13)(14)(15)(16), colorectal(17)(18), breast(19)(20), and lung(21)(22) cancers. Accumulating evidence demonstrated that obesity is a risk factor for renal structural and functional changes, leading to the end-stage renal disease which imposes a heavy economic burden on the community. Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Here is a closer look at some of the potential benefits of magnolia bark. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Before supplementing with magnolia bark, check with your medical provider to discuss proper dosage levels and ensure theres no risk of potential interactions with any medications youre taking. Some early case studies of women undergoing weight management treatment reported kidney issues caused due to a preparation containing magnolia bark, however, further analysis revealed possible contamination, adulteration, or use of substandard products as the cause of kidney damage. Whats more, magnolol likewise appears to have anticancer properties. The causative relationship between obesity and proteinuria was first reported in 1974 [1]. Kidney-shaped tray, kidney dish kidney/Renal failure - medical magnolia bark, white willow bark, white kidney bean - medical non cancerous mass in a kidney with a lesion in the middle - medical Only kidney present loss of tissue - medical pass a kidney stone more. 1The Second Hospital of Jilin University, Changchun 130041, China, 2The Kosair Children's Hospital Research Institute, Department of Pediatrics of the University of Louisville, Louisville, KY 20202, USA, 3School of Public Health, Jilin University, Changchun 130021, China, 4The First Hospital of Jilin University, Changchun 130021, China, 5Bioland Biotec Co., Ltd., Zhangjiang Modern Medical Device Park, Pudong, Shanghai 201201, China, 6Bioland R&D Center, 59 Songjeongni 2-gil, Byeongcheon, Dongnam, Cheonan, Chungnam 330-863, Republic of Korea. Ready to start planning your care? Taking magnolia bark along with drugs that promote sleep or treat. The mixture also increased serotonin metabolite levels in the frontal cortex, striatum, and nucleus accumbens at 40 mg/kg. Kim YJ, Choi MS, Cha BY, et al. Planta Med. AltMedDex Consults: "Hou po -- Chinese herb mini-review.". Some early case studies of women undergoing weight management treatment reported kidney issues caused due to a preparation containing magnolia bark, however, further analysis revealed possible contamination, adulteration, or use of substandard products as the cause of kidney damage. (9 Effects on Males). A 2018 review of 44 articles on the safety and toxicity of honokiol and magnolol (compounds in Magnolia Bark) determined that its generally considered safe for human consumption for most people when used orally and for the short term. Garrison R, Chambliss WG. Sometimes acute kidney failure causes no signs or symptoms and is detected through lab tests done for another reason. Algal leaf spot is a disease that affects trees and shrubs with thin, leathery leaves. Epub 2012 Jul 4. Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Introducing the aspect of non-pharmacological treatment of diabetes . Moreover, the organic components such as magnolol and honokiol found in the extract have strong antioxidant properties, which may help fight free radicals off the skin. What Is Elecampane Root, and Does It Have Benefits? In general, the tree rarely dies from this disease. Magnolol induces apoptosis via caspase-independent pathways in non-small cell lung cancer cells. This study was supported, in part, by Chungbuk Technopark Grant Bio-International Collaborating Research, funded by Chungbuk Province, Republic of Korea, and a collaborative project between University of Louisville and Bioland Co. Ltd. for Screening Antidiabetes and/or Obesity Naturally Extracted Compounds, funded by Bioland Co., Ltd. (10-0826 Bioland). A second study of the same magnolia and phellodendron bark extract in 56 adults observed that consuming 500 mg of the extract per day resulted in significantly lower cortisol levels and improved mood (25). Botanical medicine can be used to help forestall the need for dialysis by treating the causes and effects of renal failure, as . However, no effective medicine treating this disease is available. The bark contains the active constituents magnolol and honokiol. Walker JM, Maitra A, Walker J, et al. Wetwood is a disease that affects the trunk and branches of magnolia trees. Skin whitener: helps fade dark spots and gives the appearance of an even complexion. This result is significant as high cortisol levels have been strongly linked to high blood pressure. Magnolia Bark 1800 mg 180 Vegetarian Caps (Non-GMO, Extract 4:1 & Gluten-Free) Supports Healthy Weight, Calm Mood and Liver Functions*, Creative Commons Attribution 4.0 International License. Chen CR, Zhou XZ, Luo YJ, Huang ZL, Urade Y, Qu WM. Sarrica A, Kirika N, Romeo M, Salmona M, Diomede L. Safety and Toxicology of Magnolol and Honokiol. Magnolia bark can have interactions with the following classes of drugs: Magnolia bark can cause addiction given its sedative effects. 2011 Feb;63(1):11-7. In animal models of prostate cancer with bone metastasis, honokiol induced apoptosis via caspase-3,-8, and -9 activation and poly (ADP-ribose) polymerase (PARP) cleavage(37). 1994 Feb 9;47(3):549-53. doi: 10.1016/0006-2952(94)90187-2. Sulforaphane, isolated from cabbage and broccoli, is another Nrf2 activator and regulates Nrf2 by disassociating Nrf2 from its inhibitor Kelch-like ECH-associated protein 1 and subsequently facilitating Nrf2 into the nucleus [39]. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. What are the Side Effects of Magnolia Bark? A product that contains myclobutanil works best. Poivre M, Duez P. Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents. BL153 upregulated renal PGC-1 and NQO1 expression. During the six-month feeding, body weight was measured every month, and the gavage volume was justified based on the body weight change. Once worked as a pivotal mediator in glycolysis by catalyzing the phosphorylation of glucose to generate glucose 6-phosphate [32], HK II has emerged to play a role in oxidative stress recently [33, 34]. They enter the tree through wounds or cracks in the bark. 2008 Oct;15(10):808-14. doi: 10.1016/j.phymed.2008.04.012. Urine albumin (Bethyl Laboratories, Montgomery, TX) and urinary creatinine (BioAssay Systems, Hayward, CA) were measured according to the manufacturers' instructions. Epub 2016 Oct 6. Honokiol exhibits enhanced antitumor effects with chloroquine by inducing cell death and inhibiting autophagy in human non-small cell lung cancer cells. Data were collected from five animals for each group and presented as means SD. They are used in cosmetic and weight loss products, and their use as anti-cancer, antioxidative, and anti-inflammatory agents is being studied. A number of anticancer mechanisms have been identified with magnolol. Weakness. Furthermore, its best to speak with your healthcare provider before taking magnolia bark supplements, especially if youre currently using other supplements or medications. The Best Supplements for Healthy Digestion, How to Get the Protective Power of Vitamin K, Lessen inflammation from rheumatoid arthritis, Improve heart health. Pregnant women and breastfeeding mothers should avoid taking Magnolia Bark. During the trial, the treatment group consumed Magnolia along with Phellodendron extract 3 times a day for 6 weeks. Xu et al. I had some severe pains in my kidneys and started taking this product before bed each night. Oxidative stress also appears to play a significant role in many changes in the body and mind that accompany aging (11). This is a rather serious disease that can lead to the death of the tree if left untreated. Spoto B, Mattace-Raso F, Sijbrands E, et al. Bacterial blight prefers cool and humid conditions best. Magnolia bark may alter the effects of drugs that affect the functioning of the cytochrome P450 enzyme. Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway. A 2018 review of 44 articles on the safety and toxicity of the honokiol and magnolol compounds in magnolia bark determined that the substances are safe for human consumption (1). Modulation of P-glycoprotein expression by honokiol, magnolol and 4-O-methylhonokiol, the bioactive components of. Honokiol Inhibits Constitutive and Inducible STAT3 Signaling via PU.1-Induced SHP1 Expression in Acute Myeloid Leukemia Cells. Oxidative stress and subsequent inflammation are one cause of chronic conditions like diabetes, cancer, heart disease, and neurodegenerative diseases like Alzheimers (9, 10). The authors declare that they have no conflict of interests. This review will focus on the clinically relevant inflammatory molecules that play a role in CKD . The spots often have something like flakes on them. Does dihydrohonokiol, a potent anxiolytic compound, result in the development of benzodiazepine-like side effects? Monday through Friday, 8 a.m. to 6 p.m. (Eastern time), Monday through Friday, 9 a.m. to 5 p.m. (Eastern time), Monday to Friday, 8 a.m. to 6 p.m. (Eastern time). Collect all of the fallen leaves around the magnolia. Pillon NJ, Croze ML, Vella RE, Soulre L, Lagarde M, Soulage CO. You cannot get magnolia naturally from foods. Avoid keeping the ground around the magnolia constantly moist. Corticosterone and serotonin each play a role in regulating anxiety, mood, and depression. Li Y, Tong X, Rumala C, Clemons K, Wang S. Thrombospondin1 deficiency reduces obesity-associated inflammation and improves insulin sensitivity in a diet-induced obese mouse model. Molecules. Interactions. "Magnoliae Officinalis Cortex" [Hou Po ()] is the dried stem bark, root bark, or branch bark of Magnolia officinalis Rehder & E.H.Wilson or M. officinalis var. However, all these structure alterations were alleviated after six months of BL153 treatment at a dose of 5mg/kg or 10mg/kg (Figure 2). Aside from neolignans, more than 200 chemical compounds have been isolated from the tree (5). Shen Y, Pang EC, Xue CC, Zhao ZZ, Lin JG, Li CG. The magnolia extract improved health issues such as anxiety, insomnia, depression, and libido. Chronic kidney failure is a significant problem in modern society. Moreover, our results showed that PGC-1 was slightly elevated in the kidney of HFD-fed mice. Magnolia bark is a staple of traditional Chinese medicine and is used today for a variety of potential health benefits ranging from the treatment of depression and insomnia to improving oral health. Since here the treatment is longer than that, we also included one low dose of BL153 at 2.5mg/kg. Spray the wound with alcohol; you can even pour some alcohol into the wound. Control groups were given same volume of ddH2O with 0.05% ethanol. The houpo magnolia tree is native to China, where it has been used for thousands of years as a supplement in traditional Chinese medicine. Remove all dead tissue with sharp and sterile tools. If the sore is on the trunk, carefully clean it with a sharp knife. Front Neurol. However, long-term use is not recommended due to a lack of safety data. Hellstrm MK, Ramberg P. The effect of a dentifrice containing Magnolia extract on established plaque and gingivitis in man: a six-month clinical study. Weisinger JR, Kempson RL, Eldridge FL, Swenson RS.